Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14184301 | 0.88 | ALDH1A1 (0.56) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL5023295 | 0.86 | MAPT (0.67) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL2330387 | 0.76 | ALDH1A1 (0.73) | KDM4ERAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5022653 | 0.73 | MAPT (0.65) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL14880185 | 0.73 | CYP2C19 (0.67) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL14364602 | 0.71 | LMNA (0.59) | KDM4EKMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL23565700 | 0.71 | ROCK2 (0.62) | KDM4ERAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL13966176 | 0.70 | L3MBTL1 (0.64) | KDM4ERAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9678478 | 0.70 | GAA (0.50) | MEN1KMT2ARAB9AMAPTNPC1 | |
| SCHEMBL17318522 | 0.69 | HDAC1 (0.70) | MEN1KMT2ARAB9ACYP2C19GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554262-B1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD (IN) | 2007-12-05 | — | — | EP | disclosed |
| WO-2004037805-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-05-06 | — | — | WO | disclosed |