Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13966184 | 0.88 | NPC1 (0.59) | L3MBTL1HDAC3HDAC1HDAC2MAPT | |
| SCHEMBL4531531 | 0.84 | L3MBTL1 (0.64) | L3MBTL1ALDH1A1HTTALOX15HDAC3 | |
| SCHEMBL28677805 | 0.81 | ALDH1A1 (0.78) | L3MBTL1ALDH1A1HTTALOX15HDAC3 | |
| SCHEMBL23565700 | 0.80 | ROCK2 (0.62) | L3MBTL1ALDH1A1HTTALOX15HDAC3 | |
| SCHEMBL2330387 | 0.80 | ALDH1A1 (0.73) | L3MBTL1ALDH1A1HTTALOX15HDAC3 | |
| SCHEMBL6378760 | 0.76 | HTT (0.66) | L3MBTL1ALDH1A1HTTALOX15HDAC3 | |
| SCHEMBL10473593 | 0.76 | RAB9A (0.62) | L3MBTL1ALDH1A1HTTALOX15HDAC1 | |
| SCHEMBL21870357 | 0.76 | HDAC3 (0.62) | L3MBTL1ALDH1A1HTTALOX15HDAC3 | |
| SCHEMBL27830592 | 0.75 | LMNA (0.56) | L3MBTL1ALDH1A1HTTALOX15HDAC3 | |
| SCHEMBL2418750 | 0.75 | ALDH1A1 (0.62) | L3MBTL1ALDH1A1HTTALOX15HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482342-B2 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2009-01-27 | — | — | US | disclosed |
| US-7482342-B2 | Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors | SANOFI-AVENTIS (FR) | 2009-01-27 | — | — | US | disclosed |