Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 17/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 15/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 15/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 14/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061768 | 1.00 | GABRA5 (0.60) | GABRA5GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL8422919 | 0.90 | GABRA5 (0.62) | GABRA5GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL8422923 | 0.90 | GABRA5 (0.62) | GABRA5GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL13524277 | 0.89 | GABRA3 (0.57) | GABRA5GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL8359194 | 0.89 | GABRA5 (0.76) | GABRA5GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL8359208 | 0.89 | GABRA5 (0.76) | GABRA5GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL8360463 | 0.89 | GABRA3 (0.57) | GABRA5GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL8363053 | 0.88 | GABRA5 (0.61) | GABRA5GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL13524276 | 0.88 | GABRA5 (0.61) | GABRA5GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL7726574 | 0.88 | GABRG2 (0.61) | GABRA5GABRG2GABRB3GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317619-A1 | Selective Agents for Pain Suppression | COOK JAMES | 2010-12-16 | — | — | US | disclosed |
| US-20100261711-A1 | SELECTIVE ANTICONVULSANT AGENTS AND THEIR USES | WISYS TECHNOLOGY FOUNDATION (US) | 2010-10-14 | — | — | US | disclosed |
| US-7618958-B2 | Convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnosis; Ethyl 8-bromo-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate | WISYS TECHNOLOGY FOUNDATION, INC. (US) | 2009-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317619-A1 | Selective Agents for Pain Suppression | CNR2, CNR1, OPRL1 | GABRA5 5/4885GABRG2 25/4885GABRB3 7/4885 |
| US-20100261711-A1 | SELECTIVE ANTICONVULSANT AGENTS AND THEIR USES | GABRA5, GABRA6, GABRA2 | GABRA5 1/4885GABRG2 11/4885GABRB3 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.