Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 5/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359258 | 0.89 | ACHE (0.71) | SLC6A5ACHEPARP1HDAC1HDAC6 | |
| SCHEMBL29915094 | 0.88 | SLC6A5 (0.61) | SLC6A5MEN1KMT2AATMGAA | |
| SCHEMBL8360515 | 0.86 | HTR1A (0.61) | SLC6A5MEN1KMT2AATMGAA | |
| SCHEMBL4144313 | 0.85 | SLC6A5 (1.00) | SLC6A5MEN1KMT2AATMGAA | |
| SCHEMBL8363111 | 0.81 | PARP1 (0.77) | SLC6A5MEN1KMT2AGAAPARP1 | |
| SCHEMBL8360513 | 0.80 | PARP1 (0.77) | SLC6A5PARP1 | |
| SCHEMBL2344021 | 0.79 | SLC6A5 (0.71) | SLC6A5MEN1KMT2AATMGAA | |
| SCHEMBL8359246 | 0.77 | PARP1 (0.68) | PARP1HDAC1HDAC6 | |
| SCHEMBL8359382 | 0.77 | ACHE (0.73) | SLC6A5ACHEPARP1HDAC1HDAC6 | |
| SCHEMBL8359525 | 0.77 | ACHE (0.73) | SLC6A5ACHEHDAC1HDAC6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247641-B2 | Compounds, derivatives, compositions, preparation and uses | MGI GP, INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7247641-B2 | Compounds, derivatives, compositions, preparation and uses | MGI GP, INC. (US) | 2007-07-24 | — | — | US | disclosed |
| WO-2003014121-A9 | COMPOUNDS, DERIVATIVES, COMPOSITIONS, PREPARATION AND USES | GUILFORD PHARM INC (US) | 2004-03-25 | — | — | WO | disclosed |
| WO-2003014121-A1 | COMPOUNDS, DERIVATIVES, COMPOSITIONS, PREPARATION AND USES | GUILFORD PHARMACEUTICALS INC. (US) | 2003-02-20 | — | — | WO | disclosed |