Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 4/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | AHCY | P23526 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | KAT7 | O95251 | 1/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360870 | 0.86 | NR1D1 (0.48) | STSRORCNR1D1KMT2AMEN1 | |
| SCHEMBL8360879 | 0.85 | JAK2 (0.51) | STSRORCNR1D1KMT2AMEN1 | |
| SCHEMBL2331964 | 0.79 | ALDH1A1 (0.51) | NR1D1KMT2AMEN1PSEN1PSEN2 | |
| SCHEMBL2337474 | 0.78 | MEN1 (0.44) | STSNR1D1KMT2AMEN1AHCY | |
| SCHEMBL2337471 | 0.78 | MEN1 (0.44) | STSNR1D1KMT2AMEN1AHCY | |
| SCHEMBL8363938 | 0.78 | CNR1 (0.46) | KMT2AMEN1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL8360876 | 0.78 | KCNA5 (0.55) | STSRORCKMT2AMEN1ALDH1A1 | |
| SCHEMBL8363935 | 0.77 | MEN1 (0.46) | RORCKMT2AMEN1PSEN1PSEN2 | |
| SCHEMBL8360877 | 0.77 | JAK2 (0.52) | STSRORCKMT2AMEN1ALDH1A1 | |
| SCHEMBL8363933 | 0.77 | KMT2A (0.54) | RORCKMT2AMEN1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013527-A1 | SULFONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |