Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GABRP | O00591 | 2/20 | 0.47 |
| ▸ | GABRD | O14764 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.47 |
| ▸ | GABRE | P78334 | 2/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28509281 | 0.84 | NNMT (0.47) | MAP4K4 | |
| SCHEMBL16808037 | 0.82 | ATR (0.37) | TPMTGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL21912461 | 0.80 | GABRP (0.47) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30884164 | 0.79 | ALDH1A1 (0.50) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7216707 | 0.79 | ALDH1A1 (0.50) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23774876 | 0.79 | MGAM (0.42) | TPMTALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL836245 | 0.78 | PDGFRB (0.51) | ALDH1A1KDM4ELMNAHSD17B10POLB | |
| SCHEMBL28505548 | 0.78 | SCN9A (0.52) | MAP4K4 | |
| Hydrochloric Acid SCHEMBL23757654 | 0.78 | MGAM (0.41) | TPMTALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL2805912 | 0.78 | GABRP (0.48) | ALDH1A1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662227-B | O-aminopyridine alkyne compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-07-05 | — | — | CN | disclosed |
| EP-3753935-A1 | SUBSTITUTED DIALKYL(OXIDO)-LAMBDA4-SULFANYLIDENE NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3753935-A1 | SUBSTITUTED DIALKYL(OXIDO)-LAMBDA4-SULFANYLIDENE NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2020-12-23 | — | — | EP | disclosed |
| CN-111662227-A | O-aminopyridine alkyne compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2020-09-15 | — | — | CN | disclosed |
| EP-3080105-B1 | SUBSTITUTED DIALKYL(OXIDO)-LAMBDA4-SULFANYLIDENE NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3080105-B1 | SUBSTITUTED DIALKYL(OXIDO)-LAMBDA4-SULFANYLIDENE NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2020-09-02 | — | — | EP | disclosed |
| CN-105916850-B | Substituted dialkyl (oxyalkylene) - Λ as kinase inhibitors4-sulfanylidenenicotinamide derivatives | 阿勒根公司 | 2020-03-20 | — | — | CN | disclosed |
| CN-105814021-B | Substituted nicotinamide derivatives as kinase inhibitors | 阿勒根公司 | 2020-03-13 | — | — | CN | disclosed |
| EP-3080084-B1 | SUBSTITUTED NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-06-13 | — | — | EP | disclosed |
| EP-3080084-B1 | SUBSTITUTED NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-06-13 | — | — | EP | disclosed |
| US-7915443-B2 | Sulfoximines as kinase inhibitors | ALLERGAN, INC. (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915443-B2 | Sulfoximines as kinase inhibitors | ALLERGAN, INC. (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915443-B2 | Sulfoximines as kinase inhibitors | ALLERGAN, INC. (US) | 2011-03-29 | — | — | US | disclosed |
| WO-2010078393-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| EP-2099757-A2 | SULFOXIMINES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| US-20090196906-A1 | Kinase inhibitors | ALLERGAN, INC. | 2009-08-06 | — | — | US | disclosed |
| US-20090099181-A1 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099181-A1 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090099181-A1 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN, INC. | 2009-04-16 | — | — | US | disclosed |
| WO-2008061236-A2 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090196906-A1 | Kinase inhibitors | PTK2, MAP3K6, MAP3K20 | TPMT 2587/4885ALDH1A1 2605/4885GABRP 2308/4885 |
| US-20090099181-A1 | SULFOXIMINES AS KINASE INHIBITORS | SRC, PTK2B, TYRO3 | TPMT 813/4885ALDH1A1 2320/4885GABRP 2067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.