SCHEMBL8366197

SCHEMBL8366197

CCOC(=O)C=C(C#N)c1cc(OC)c(OC)c(OC)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51
ALDH1A1 P00352 1/20 0.51
KMT2A Q03164 1/20 0.51
TUBB4A P04350 4/20 0.50
TUBB P07437 4/20 0.50
TUBA3C P0DPH7 4/20 0.50
TUBA1B P68363 4/20 0.50
TUBA4A P68366 4/20 0.50
TUBB4B P68371 4/20 0.50
TUBB3 Q13509 4/20 0.50
TUBB2A Q13885 4/20 0.50
TUBB8 Q3ZCM7 4/20 0.50
TUBA3E Q6PEY2 4/20 0.50
TUBA1A Q71U36 4/20 0.50
TUBA1C Q9BQE3 4/20 0.50
TUBB6 Q9BUF5 4/20 0.50
TUBB2B Q9BVA1 4/20 0.50
TUBB1 Q9H4B7 4/20 0.50
PDE4A P27815 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23530141 0.89 PKM (0.44) KDM4EMEN1ALDH1A1KMT2ATUBB4A
SCHEMBL10678693 0.88 ALDH1A1 (0.41) KDM4EMEN1ALDH1A1KMT2ATUBB4A
SCHEMBL11856079 0.86 HSD17B2 (0.40) KDM4EMEN1ALDH1A1KMT2ATUBB4A
SCHEMBL8364475 0.85 PDE4B (0.54) KDM4EMEN1ALDH1A1KMT2APDE4A
SCHEMBL11346406 0.85 ALDH1A1 (0.39) KDM4EMEN1ALDH1A1KMT2ATUBB4A
SCHEMBL8646387 0.81 TUBB4A (0.56) KDM4EALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL11762856 0.80 TUBB4A (0.55) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL21457468 0.78 NQO2 (0.50) KDM4EMEN1ALDH1A1KMT2ANQO1
SCHEMBL23866739 0.78 NQO2 (0.50) KDM4EMEN1ALDH1A1KMT2ANQO1
SCHEMBL11762780 0.77 CES2 (0.49) KDM4EMEN1ALDH1A1KMT2APDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999036049-A1 PHOTOSTABLE UV ABSORBENT CONTAINING α-CYANO CINNAMYL MOIETY ISP INVESTMENTS INC. (US) 1999-07-22 WO disclosed