Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.38 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 7/20 | 0.43 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304880 | 0.99 | HTR4 (0.44) | HTR4ACHEHTR3AEIF2AK3FGFR1 | |
| SCHEMBL8305104 | 0.87 | HTR4 (0.44) | HTR4 | |
| Bromide SCHEMBL7937589 | 0.86 | HTR4 (0.45) | HTR4NPC1 | |
| Hydrochloric Acid SCHEMBL8368070 | 0.86 | HTR4 (0.43) | HTR4 | |
| SCHEMBL7808395 | 0.85 | HTR4 (0.45) | HTR4NPC1 | |
| SCHEMBL7804908 | 0.84 | HTR4 (0.48) | HTR4NPC1 | |
| SCHEMBL8308838 | 0.82 | DRD4 (0.38) | HTR4SUV39H2 | |
| SCHEMBL8309549 | 0.80 | ACHE (0.51) | HTR4ACHE | |
| Bromide SCHEMBL7744559 | 0.80 | HTR4 (0.36) | HTR4ACHE | |
| SCHEMBL7750256 | 0.79 | SUV39H2 (0.35) | HTR4HTR3ASUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929089-A | ANTISEROTONINE AGENT | SYNTHELABO (FR) | 1999-07-27 | — | — | US | disclosed |