Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598216 | 0.84 | DRD2 (0.67) | ADRA1DADRA1AADRA1BSLC6A2SLC6A4 | |
| SCHEMBL7596308 | 0.80 | ADRA1D (0.63) | ADRA1DADRA1AADRA1BSLC6A2SLC6A3 | |
| SCHEMBL7601726 | 0.78 | ADRA1D (0.67) | ADRA1DADRA1AADRA1BSLC6A2SLC6A3 | |
| SCHEMBL7602249 | 0.77 | ADRA1D (0.77) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL6433355 | 0.76 | CNR1 (0.61) | — | |
| SCHEMBL7603599 | 0.75 | ADRA1D (0.63) | ADRA1DADRA1AADRA1BSLC6A2SLC6A3 | |
| SCHEMBL7596185 | 0.75 | DRD2 (0.66) | ADRA1ASLC6A2SLC6A4DRD2DRD4 | |
| SCHEMBL8975590 | 0.75 | RAB9A (0.80) | ADRA1DADRA1AADRA1BSLC6A2SLC6A3 | |
| SCHEMBL6434428 | 0.74 | CNR1 (0.60) | — | |
| SCHEMBL8370598 | 0.72 | OPRM1 (0.44) | ADRA1ADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891344-A1 | ALPHA 1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997037983-A1 | α1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1997-10-16 | — | — | WO | disclosed |