SCHEMBL8370837

SCHEMBL8370837

Nc1cc(OC(=O)Oc2cc(N)c(F)cc2Cl)c(Cl)cc1F

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.37
GAA P10253 4/20 0.37
CUL4A Q13619 2/20 0.34
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
POLB P06746 3/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
FADS1 O60427 1/20 0.32
FABP7 O15540 1/20 0.32
FABP3 P05413 1/20 0.32
FABP5 Q01469 1/20 0.32
SLC9A1 P19634 1/20 0.32
APEX1 P27695 1/20 0.31
MRGPRX4 Q96LA9 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8084592 0.90 CUL4A (0.46) NPC1GAACUL4AMAPTRAB9A
SCHEMBL27298534 0.87 NPC1 (0.36) NPC1GAAMAPTRAB9APOLB
SCHEMBL8604258 0.86 CUL4A (0.49) NPC1GAACUL4AMAPTRAB9A
SCHEMBL8600593 0.86 ELANE (0.36) NPC1GAACUL4AMAPTRAB9A
SCHEMBL8602332 0.86 RORC (0.35) NPC1GAACUL4AMAPTRAB9A
SCHEMBL17466053 0.86 KDM4E (0.42) NPC1GAAMAPTRAB9APOLB
SCHEMBL8598264 0.85 RORC (0.35) NPC1GAARAB9AHPGD
SCHEMBL8603914 0.83 CUL4A (0.39) GAACUL4AALDH1A1L3MBTL1
SCHEMBL8898256 0.82 NPC1 (0.55) NPC1GAACUL4APOLBALDH1A1
SCHEMBL8540923 0.82 HDAC1 (0.35) RAB9AALDH1A1HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5043525-A None JP disclosed
EP-0659735-B1 PROCESS FOR PRODUCING ANILINE DERIVATIVE SAGAMI CHEM RES (JP) 1999-01-13 EP disclosed
US-5639915-A Process for the production of aniline derivatives SAGAMI CHEMICAL RESEARCH CENTER (JP) 1997-06-17 US disclosed
EP-0635485-B1 TETRAHYDROPHTHALAMIDE DERIVATIVE, INTERMEDIATE FOR PRODUCING THE SAME, PRODUCTION OF BOTH, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT SAGAMI CHEM RES (JP) 1997-06-11 EP disclosed
US-5554581-A Tetrahydrophthalamide derivative, intermediate for producing the same, production of both, and herbicide containing the same as active ingredient SAGAMI CHEMICAL RESEARCH CENTER (JP) 1996-09-10 US disclosed
EP-0496347-B1 Methods of preparing fluorobenzene derivatives and related compounds SAGAMI CHEM RES (JP) 1996-09-04 EP disclosed
US-5506190-A Tetrahydrophthalamide derivative, intermediate for producing the same, production of both, and herbicide containing the same as active ingredient SAGAMI CHEMICAL RESEARCH CENTER (JP) 1996-04-09 US disclosed
EP-0659735-A1 PROCESS FOR PRODUCING ANILINE DERIVATIVE SAGAMI CHEMICAL RESEARCH CENTER (JP) 1995-06-28 EP disclosed
US-5391807-A Methods of preparing fluorobenzene derivatives and related compounds SAGAMI CHEMICAL RESEARCH CENTER (JP) 1995-02-21 US disclosed
EP-0635485-A1 TETRAHYDROPHTHALAMIDE DERIVATIVE, INTERMEDIATE FOR PRODUCING THE SAME, PRODUCTION OF BOTH, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT SAGAMI CHEMICAL RESEARCH CENTER (JP) 1995-01-25 EP disclosed
US-5344953-A Fluorobenzene derivatives SAGAMI CHEMICAL RESEARCH CENTER (JP) 1994-09-06 US disclosed
US-5281742-A Bis(fluorophenyl) carbonate derivatives SAGAMI CHEMICAL RESEARCH CENTER (JP) 1994-01-25 US disclosed
JP-H0543525-A DIPHENYL CARBONATE DERIVATIVE AND ITS PRODUCTION SAGAMI CHEM RES CENTER 1993-02-23 JP disclosed
EP-0496347-A2 Methods of preparing fluorobenzene derivatives and related compounds SAGAMI CHEMICAL RESEARCH CENTER (JP) 1992-07-29 EP disclosed