SCHEMBL837413

SCHEMBL837413

N[C@@H](Cc1c[nH]c2c(Cl)cccc12)C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNF P01375 1/20 0.64
KMT2A Q03164 3/20 0.62
KDM4E B2RXH2 2/20 0.62
LMNA P02545 2/20 0.62
MAPT P10636 2/20 0.62
TSHR P16473 2/20 0.62
BLM P54132 2/20 0.62
PMP22 Q01453 2/20 0.62
MEN1 O00255 2/20 0.62
MPO P05164 1/20 0.62
HIF1A Q16665 1/20 0.62
HTR2A P28223 2/20 0.55
SLC6A4 P31645 2/20 0.51
ALDH1A1 P00352 1/20 0.51
CYP3A4 P08684 1/20 0.51
HTR1A P08908 1/20 0.51
ADORA3 P0DMS8 1/20 0.51
ALOX15 P16050 1/20 0.51
NFKB1 P19838 1/20 0.51
HTR2C P28335 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30495964 1.00 TNF (0.64) TNFKMT2AKDM4ELMNAMAPT
SCHEMBL18028962 1.00 TNF (0.64) TNFKMT2AKDM4ELMNAMAPT
SCHEMBL3467251 1.00 TNF (0.64) TNFKMT2AKDM4ELMNAMAPT
SCHEMBL838121 1.00 TNF (0.64) TNFKMT2AKDM4ELMNAMAPT
SCHEMBL19846988 0.88 HTR2A (0.54) TNFKMT2AKDM4ELMNAMAPT
SCHEMBL1460647 0.86 MAPT (0.69) TNFKMT2AKDM4ELMNAMAPT
SCHEMBL18029110 0.86 MAPT (0.69) TNFKMT2AKDM4ELMNAMAPT
SCHEMBL1460650 0.86 MAPT (0.69) TNFKMT2AKDM4ELMNAMAPT
SCHEMBL24328355 0.84 SMN1; SMN2 (0.61) TNFKMT2AKDM4ELMNAMAPT
SCHEMBL20816074 0.84 MAPT (0.63) TNFKMT2AKDM4ELMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240260865-A1 METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS CALIFORNIA INSTITUTE OF TECHNOLOGY 2024-08-08 US claimed
CN-118207197-A Immobilization of thermophilic archaea tryptophan synthase on magnetic bead-T4 phage capsid composite carrier 江苏海洋大学 2024-06-18 CN claimed
US-11903708-B2 Switchable low voltage electrochemical sensing for interfering species rejection CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2024-02-20 US claimed
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 CN claimed
US-11690544-B2 Method of producing thin enzyme-based sensing layers on planar sensors CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2023-07-04 US claimed
CN-111118048-B Use of chimeric phenylalanyl-tRNA synthetases/tRNAs 浙江大学 2022-06-10 CN claimed
US-20200247858-A1 AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF FOG PHARMACEUTICALS, INC. (US) 2020-08-06 US claimed
EP-3678683-A2 AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF Fog Pharmaceuticals, Inc. (US) 2020-07-15 EP claimed
CN-111372942-A β -catenin function modulating agents and methods thereof 弗格制药有限公司 2020-07-03 CN claimed
WO-2019051327-A2 AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF FOG PHARMACEUTICALS, INC. (US) 2019-03-14 WO claimed
EP-3335720-A1 C-DI-GMP BINDING PEPTIDES Universität Basel (CH) 2018-06-20 EP claimed
US-6117670-A NUCLEIC ACID SEQUENCE THAT CODES AN ENZYMATIC PROTEIN WHICH PREVENTS INFECTION AND PROPAGATION OF PHYTOPATHOGENS IN PLANTS; FOR BIOLOGICAL PEST CONTROL; BACTERICIDES NOVARTIS FINANCE CORPORATION (US) 2000-09-12 US claimed
US-5817502-A GENETIC ENGINEERING; GENE EXPRESSION OF A POLYPEPTIDE NOVARTIS FINANCE CORPORATION (US) 1998-10-06 US claimed
US-20260071243-A1 BIOLOGICAL PRODUCTION OF TRYPTOPHAN-DERIVED PRODUCTS UNIV TEXAS (US) 2026-03-12 US disclosed
US-20260022515-A2 PROCESS FOR DYEING TEXTILES SANKO TEKSTIL ISLETMELERI SAN VE TIC AS (TR) 2026-01-22 US disclosed
US-20250354108-A1 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS UNIV DANMARKS TEKNISKE (DK) 2025-11-20 US disclosed
EP-1132480-A1 Method for producing halo-L-tryptophan Ajinomoto Co., Inc. (JP) 2001-09-12 EP disclosed
WO-2001044447-A1 COMPOSITIONS AND METHODS FOR HALOGENATION REACTIONS SYNGENTA PARTICIPATIONS AG (CH) 2001-06-21 WO disclosed
US-6117670-A NUCLEIC ACID SEQUENCE THAT CODES AN ENZYMATIC PROTEIN WHICH PREVENTS INFECTION AND PROPAGATION OF PHYTOPATHOGENS IN PLANTS; FOR BIOLOGICAL PEST CONTROL; BACTERICIDES NOVARTIS FINANCE CORPORATION (US) 2000-09-12 US disclosed
US-5817502-A GENETIC ENGINEERING; GENE EXPRESSION OF A POLYPEPTIDE NOVARTIS FINANCE CORPORATION (US) 1998-10-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260022515-A2 PROCESS FOR DYEING TEXTILES TDO2, TPH2, IDO2 TNF 2010/4885KMT2A 693/4885KDM4E 522/4885
US-20200247858-A1 AGENTS MODULATING BETA-CATENIN FUNCTIONS AND METHODS THEREOF CTNNB1, CTNNBL1, CTNNA1 TNF 2185/4885KMT2A 3036/4885KDM4E 1902/4885
US-20260071243-A1 BIOLOGICAL PRODUCTION OF TRYPTOPHAN-DERIVED PRODUCTS TPH1, TPH2, SLC6A4 TNF 2121/4885KMT2A 1283/4885KDM4E 3485/4885
US-20250354108-A1 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS INMT, KARS1, MIA3 TNF 4064/4885KMT2A 445/4885KDM4E 2243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.