Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27315064 | 0.90 | ALDH1A1 (0.50) | LMNAALDH1A1POLBTAS1R3TAS1R1 | |
| SCHEMBL9423028 | 0.84 | HTT (0.62) | LMNAALDH1A1POLBTAS1R3TAS1R1 | |
| SCHEMBL8376633 | 0.83 | LMNA (0.53) | LMNARECQLALDH1A1POLBHSD17B10 | |
| SCHEMBL9429690 | 0.83 | GPBAR1 (0.60) | LMNARECQLPOLBGFERPTGS2 | |
| SCHEMBL9871174 | 0.81 | PTGS2 (0.62) | LMNARECQLALDH1A1GFERPTGS2 | |
| SCHEMBL9429244 | 0.81 | NPC1 (0.56) | LMNARECQLALDH1A1POLBGFER | |
| SCHEMBL7880670 | 0.80 | LMNA (0.56) | LMNARECQLGFEREPAS1PTGS2 | |
| SCHEMBL22609268 | 0.79 | DHODH (0.43) | LMNAALDH1A1POLBALOX15HSD17B10 | |
| SCHEMBL8377819 | 0.79 | KMT2A (0.54) | LMNARECQLALDH1A1POLBGFER | |
| SCHEMBL8376637 | 0.77 | LMNA (0.57) | LMNARECQLALDH1A1PTGS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573318-B1 | 4-Phenylcarbamoyl-3-isoxazolecarboxylic acid derivatives with antiinflammatory activity | HOECHST MARION ROUSSEL INC (FR) | 1999-03-24 | — | — | EP | disclosed |
| US-5371099-A | Antiinflammatory agents | ROUSSEL-UCLAF (FR) | 1994-12-06 | — | — | US | disclosed |
| EP-0573318-A1 | Phenyl carboxamide isoxazole derivatives and salts, process for their preparation and the new intermediates thereof. Their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1993-12-08 | — | — | EP | disclosed |