Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7880670 | 0.88 | LMNA (0.56) | PTGS2SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL9429690 | 0.84 | GPBAR1 (0.60) | PTGS2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9429244 | 0.82 | NPC1 (0.56) | PTGS2SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL20006969 | 0.81 | MAPK1 (0.72) | PTGS2SMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL8375488 | 0.81 | LMNA (0.54) | PTGS2SMN1; SMN2GAALMNARECQL | |
| SCHEMBL9428749 | 0.81 | LMNA (0.46) | PTGS2SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL8379618 | 0.80 | LMNA (0.54) | PTGS2SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL8375473 | 0.80 | PTGS2 (0.65) | PTGS2SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL8377819 | 0.80 | KMT2A (0.54) | NPC1RAB9ALMNARECQLGFER | |
| SCHEMBL8376637 | 0.78 | LMNA (0.57) | PTGS2SMN1; SMN2GAALMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | claimed |