Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 9/20 | 0.52 |
| ▸ | RAB9A | P51151 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938529 | 0.81 | NOTUM (0.61) | NOTUMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21776964 | 0.77 | NOTUM (0.71) | NOTUMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8375633 | 0.76 | RAB9A (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL8375803 | 0.76 | THRB (0.51) | NOTUMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8375802 | 0.76 | ALDH1A1 (0.61) | NPC1RAB9AALDH1A1HPGDPOLB | |
| SCHEMBL3479473 | 0.75 | MAPT (0.61) | NOTUMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14541589 | 0.75 | NOTUM (0.54) | NOTUMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20270439 | 0.75 | PIK3CD (0.42) | NOTUMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2537431 | 0.74 | MAPT (0.59) | NOTUMNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14591926 | 0.74 | MAPT (0.59) | NOTUMNPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |