Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788874 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HSD17B1HSD17B2NPC1RAB9A | |
| SCHEMBL8377265 | 0.83 | NPC1 (0.50) | ALDH1A1NPC1RAB9ATP53HDAC3 | |
| SCHEMBL38657732 | 0.83 | PTPN1 (0.61) | ALDH1A1NPC1RAB9APOLBTP53 | |
| SCHEMBL2959768 | 0.83 | NPC1 (0.56) | ALDH1A1NPC1RAB9APOLBTP53 | |
| SCHEMBL8380106 | 0.83 | RAB9A (0.57) | ALDH1A1HSD17B1HSD17B2NPC1RAB9A | |
| SCHEMBL6938529 | 0.83 | NOTUM (0.61) | ALDH1A1NPC1RAB9APOLBTP53 | |
| SCHEMBL5157687 | 0.83 | RAB9A (0.61) | ALDH1A1NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL38658113 | 0.82 | ALDH1A1 (0.43) | ALDH1A1HSD17B1HSD17B2NPC1RAB9A | |
| SCHEMBL1180676 | 0.81 | HSD17B1 (0.74) | ALDH1A1HSD17B1HSD17B2NPC1RAB9A | |
| SCHEMBL16373702 | 0.79 | ALDH1A1 (0.58) | ALDH1A1HSD17B1HSD17B2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| CN-1216986-A | Isoxazole derivatives | SANKYO CO (JP) | 1999-05-19 | — | — | CN | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |