Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375028 | 0.86 | MAPT (0.35) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8375766 | 0.84 | TSHR (0.31) | — | |
| SCHEMBL8377411 | 0.83 | TSHR (0.31) | — | |
| SCHEMBL8375800 | 0.82 | ALDH1A1 (0.33) | NPC1RAB9A | |
| SCHEMBL8377355 | 0.81 | KDM4E (0.32) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8376446 | 0.80 | MAPT (0.31) | NPC1SMN1; SMN2 | |
| SCHEMBL8378808 | 0.80 | CHRNB2 (0.33) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8377392 | 0.79 | PPARD (0.33) | — | |
| SCHEMBL8377387 | 0.77 | KCNH2 (0.30) | — | |
| SCHEMBL8377368 | 0.77 | RAB9A (0.40) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |