SCHEMBL8375778

SCHEMBL8375778

Nc1ccccc1-c1[c]cccc1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 4/20 0.46
TSHR P16473 2/20 0.46
ALDH1A1 P00352 6/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
HSD17B10 Q99714 4/20 0.39
SMN1; SMN2 Q16637 6/20 0.39
HPGD P15428 3/20 0.39
TDP1 Q9NUW8 3/20 0.39
KDM4E B2RXH2 3/20 0.39
CYP3A4 P08684 2/20 0.39
POLB P06746 2/20 0.39
BLM P54132 2/20 0.39
NPC1 O15118 2/20 0.39
CASP1 P29466 1/20 0.39
CASP7 P55210 1/20 0.39
CA12 O43570 1/20 0.39
GMNN O75496 1/20 0.39
EGFR P00533 1/20 0.39
CA2 P00918 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2373478 0.84 SMN1; SMN2 (0.46) ALOX15ALDH1A1L3MBTL1HSD17B10SMN1; SMN2
SCHEMBL7446493 0.84 ALDH1A1 (0.52) ALOX15TSHRALDH1A1L3MBTL1HSD17B10
SCHEMBL9719128 0.82 ALDH1A1 (0.56) ALOX15TSHRALDH1A1L3MBTL1HSD17B10
SCHEMBL16720271 0.77 MAPT (0.39) ALOX15ALDH1A1L3MBTL1HSD17B10SMN1; SMN2
SCHEMBL9988583 0.77 ALDH1A1 (0.46) ALOX15TSHRALDH1A1L3MBTL1HSD17B10
SCHEMBL9987899 0.77 HPGD (0.39) ALOX15TSHRALDH1A1L3MBTL1HSD17B10
SCHEMBL7995314 0.77 ALDH1A1 (0.59) ALOX15ALDH1A1L3MBTL1HSD17B10SMN1; SMN2
Catechol SCHEMBL7781189 0.76 ALOX15 (0.77) ALOX15TSHRALDH1A1L3MBTL1HSD17B10
SCHEMBL16719472 0.74 HSPA5 (0.38) ALOX15TSHRALDH1A1L3MBTL1HSD17B10
SCHEMBL3841865 0.74 CYP1A2 (0.50) ALOX15ALDH1A1L3MBTL1HSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5919990-A Reclamation of bisphenol tars as feedstock in the synthesis of aminophenylhydroxphenylalkanes GENERAL ELECTRIC COMPANY (US) 1999-07-06 US claimed
EP-0837051-A2 Synthesis of aminophenylhydroxyphenylalkanes form bisphenol tars GENERAL ELECTRIC COMPANY (US) 1998-04-22 EP claimed
US-5919990-A Reclamation of bisphenol tars as feedstock in the synthesis of aminophenylhydroxphenylalkanes GENERAL ELECTRIC COMPANY (US) 1999-07-06 US disclosed
EP-0837051-A2 Synthesis of aminophenylhydroxyphenylalkanes form bisphenol tars GENERAL ELECTRIC COMPANY (US) 1998-04-22 EP disclosed