Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719835 | 0.85 | TSHR (0.50) | ALDH1A1MEN1KMT2ANFKB1TSHR | |
| SCHEMBL2373478 | 0.84 | SMN1; SMN2 (0.46) | ALDH1A1HPGDSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL3990580 | 0.84 | CYP2A6 (0.44) | ALDH1A1HPGDSMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL8560761 | 0.82 | CYP2A6 (0.43) | ALDH1A1HPGDSMN1; SMN2KMT2ATSHR | |
| SCHEMBL16720299 | 0.80 | HSD17B10 (0.44) | ALDH1A1HPGDSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL16720053 | 0.78 | TSHR (0.45) | ALDH1A1HPGDSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL8375778 | 0.77 | ALOX15 (0.46) | ALDH1A1HPGDSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL16720271 | 0.77 | MAPT (0.39) | ALDH1A1HPGDSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL7458982 | 0.77 | CYP2A6 (0.59) | ALDH1A1HPGDSMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL10506626 | 0.77 | PLA2G7 (0.41) | ALDH1A1HPGDSMN1; SMN2KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | claimed |
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |