Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10767657 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL16720271 | 0.84 | MAPT (0.39) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL8375778 | 0.84 | ALOX15 (0.46) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL9988583 | 0.84 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL9987899 | 0.84 | HPGD (0.39) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL3841865 | 0.81 | CYP1A2 (0.50) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL16719472 | 0.81 | HSPA5 (0.38) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL9988560 | 0.79 | CA1 (0.52) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL7370333 | 0.79 | TP53 (0.52) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL16719611 | 0.79 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1HPGDHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758383-A1 | AROMATIC AMIDOTHIAZOLES, COSMETIC OR DERMATOLOGICAL PREPARATIONS CONTAINING SAID AROMATIC AMIDOTHIAZOLES, AND USE THEREOF TO COMBAT OR PREVENT UNDESIRED PIGMENTATION OF THE SKIN | Beiersdorf AG (DE) | 2014-07-30 | — | — | EP | claimed |
| WO-2013041535-A1 | AROMATIC AMIDOTHIAZOLES, COSMETIC OR DERMATOLOGICAL PREPARATIONS CONTAINING SAID AROMATIC AMIDOTHIAZOLES, AND USE THEREOF TO COMBAT OR PREVENT UNDESIRED PIGMENTATION OF THE SKIN | BEIERSDORF AG (DE) | 2013-03-28 | — | — | WO | claimed |
| US-20130039870-A1 | Cosmetic Or Dermatological Preparations With A Content Of One Or More Thiazole Derivates | BEIERSDORF AG (DE) | 2013-02-14 | — | — | US | claimed |
| EP-2549979-A2 | COSMETIC OR DERMATOLOGICAL PREPARATIONS WITH A CONTENT OF ONE OR MORE THIAZOLE DERIVATIVES | Beiersdorf AG (DE) | 2013-01-30 | — | — | EP | claimed |
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | claimed |
| WO-2011117034-A2 | COSMETIC OR DERMATOLOGICAL PREPARATIONS WITH A CONTENT OF ONE OR MORE THIAZOLE DERIVATIVES | BEIERSDORF AG (DE) | 2011-09-29 | — | — | WO | claimed |
| US-7388008-B2 | Lysine based compounds | AMBRILIA BIOPHARMA INC. (CA) | 2008-06-17 | — | — | US | claimed |
| US-20020025947-A1 | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION | 2002-02-28 | — | — | US | claimed |
| WO-2001068605-A1 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED BENZENES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-09-20 | — | — | WO | claimed |
| EP-3112348-A1 | SYNTHESIS AND ANTICANCER ACTIVITY OF ARYL AND HETEROARYL-QUINOLIN DERIVATIVES | Tairx, Inc. (TW) | 2017-01-04 | — | — | EP | disclosed |
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |
| US-8920785-B2 | Cosmetic or dermatological preparations with a content of one or more thiazole derivates | BEIERSDORF AG (DE) | 2014-12-30 | — | — | US | disclosed |
| EP-2758383-A1 | AROMATIC AMIDOTHIAZOLES, COSMETIC OR DERMATOLOGICAL PREPARATIONS CONTAINING SAID AROMATIC AMIDOTHIAZOLES, AND USE THEREOF TO COMBAT OR PREVENT UNDESIRED PIGMENTATION OF THE SKIN | Beiersdorf AG (DE) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013041535-A1 | AROMATIC AMIDOTHIAZOLES, COSMETIC OR DERMATOLOGICAL PREPARATIONS CONTAINING SAID AROMATIC AMIDOTHIAZOLES, AND USE THEREOF TO COMBAT OR PREVENT UNDESIRED PIGMENTATION OF THE SKIN | BEIERSDORF AG (DE) | 2013-03-28 | — | — | WO | disclosed |
| US-20130039870-A1 | Cosmetic Or Dermatological Preparations With A Content Of One Or More Thiazole Derivates | BEIERSDORF AG (DE) | 2013-02-14 | — | — | US | disclosed |
| EP-2549979-A2 | COSMETIC OR DERMATOLOGICAL PREPARATIONS WITH A CONTENT OF ONE OR MORE THIAZOLE DERIVATIVES | Beiersdorf AG (DE) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011117034-A2 | COSMETIC OR DERMATOLOGICAL PREPARATIONS WITH A CONTENT OF ONE OR MORE THIAZOLE DERIVATIVES | BEIERSDORF AG (DE) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130039870-A1 | Cosmetic Or Dermatological Preparations With A Content Of One Or More Thiazole Derivates | TYR, CUTA, MITF | SMN1; SMN2 4158/4885ALDH1A1 95/4885HPGD 905/4885 |
| US-20020025947-A1 | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade | TFPI, TFPI2, PLAT | SMN1; SMN2 3843/4885ALDH1A1 2669/4885HPGD 951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.