Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669553 | 0.85 | CSF1R (0.49) | DHFR | |
| SCHEMBL11286352 | 0.83 | DHFR (0.68) | DHFR | |
| SCHEMBL3937299 | 0.83 | DHFR (0.68) | DHFR | |
| SCHEMBL28876908 | 0.83 | DHFR (0.63) | DHFR | |
| SCHEMBL8380685 | 0.83 | DHFR (0.63) | DHFR | |
| SCHEMBL380792 | 0.82 | DHFR (0.67) | DHFR | |
| SCHEMBL8380918 | 0.82 | LMNA (0.66) | DHFR | |
| SCHEMBL8902607 | 0.82 | DHFR (0.46) | DHFR | |
| SCHEMBL11271533 | 0.82 | DHFR (0.62) | DHFR | |
| Water SCHEMBL28837029 | 0.81 | DHFR (0.65) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901473-A1 | NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE NOVEL COMPOUNDS | EGIS GYOGYSZERGYAR RT. (HU) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997016429-A1 | NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE NOVEL COMPOUNDS | EGIS Gyógyszergyár Rt. (HU) | 1997-05-09 | — | — | WO | disclosed |
| US-4315931-A | MICROBIOCIDES, INFECTIOUS DISEASES | BASF AKTIENGESELLSCHAFT (DE) | 1982-02-16 | — | — | US | disclosed |
| EP-0000335-B1 | ESTERS OF N-PYRIMIDINYL-CARBOXIMIDIC ACID, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM. | BASF Aktiengesellschaft (DE) | 1981-10-07 | — | — | EP | disclosed |
| US-4279899-A | MICROBIOCIDES | BASF AKTIENGESELLSCHAFT (DE) | 1981-07-21 | — | — | US | disclosed |
| US-4189581-A | BACTERICIDES, POTENTIATORS OF SULFA DRUGS | BASF AKTIENGESELLSCHAFT (DE) | 1980-02-19 | — | — | US | disclosed |
| EP-0000334-A1 | 2,4-Diamino-5-benzyl-pyrimidines, process for their preparation and medicines containing them | BASF Aktiengesellschaft (DE) | 1979-01-24 | — | — | EP | disclosed |