Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377177 | 0.87 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1EGFRQPCT | |
| SCHEMBL8376002 | 0.78 | L3MBTL1 (0.39) | KMT2AALDH1A1QPCT | |
| SCHEMBL8377218 | 0.76 | QPCT (0.40) | KMT2AALDH1A1QPCTKDM4E | |
| SCHEMBL8375998 | 0.74 | GAA (0.37) | MEN1KMT2ANPSR1ALDH1A1KDM4E | |
| SCHEMBL8377217 | 0.72 | HTR2A (0.42) | CASREPHX2MEN1KMT2A | |
| SCHEMBL6959466 | 0.72 | CASR (0.45) | CASREPHX2POLBTSHRMEN1 | |
| SCHEMBL3508765 | 0.67 | ALDH1A1 (0.43) | POLBTSHRMEN1KMT2ANPSR1 | |
| SCHEMBL3507456 | 0.66 | EPHX2 (0.41) | CASREPHX2ALDH1A1QPCTKDM4E | |
| SCHEMBL8184622 | 0.65 | CYP3A4 (0.45) | TSHRALDH1A1CNR1KDM4EHSD17B10 | |
| SCHEMBL3504318 | 0.65 | ACHE (0.41) | MEN1KMT2AALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925766-A | COGNITION ACTIVATORS FOR DECREASING CHOLINERGIC FUNCTION OF ALZHEIMER*S DISEASE AND ARE ENZYME INHIBITORS OF MONOAMINE OXIDASE AND ARE ANTIDEPRESSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5756754-A | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds | HOECHST MARION ROUSSEL, INC. (US) | 1998-05-26 | — | — | US | disclosed |