Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375998 | 0.88 | GAA (0.37) | HTR3AKMT2AMEN1MMP3GAA | |
| SCHEMBL3504561 | 0.78 | ALDH1A1 (0.46) | KMT2AMEN1GAATDP1 | |
| SCHEMBL8377218 | 0.77 | QPCT (0.40) | KMT2AGAA | |
| SCHEMBL8377107 | 0.75 | CYP1A2 (0.39) | HTR2AHTR7KCNH2EPHX2GAA | |
| SCHEMBL3504318 | 0.75 | ACHE (0.41) | KMT2AMEN1GAATDP1 | |
| SCHEMBL3505069 | 0.73 | GAA (0.45) | KMT2AMEN1GAATDP1 | |
| SCHEMBL8376002 | 0.73 | L3MBTL1 (0.39) | HTR2ADRD2KMT2AGAA | |
| SCHEMBL3505067 | 0.73 | ACHE (0.40) | HTR2AKCNH2DRD2MMP3EPHX2 | |
| SCHEMBL6951018 | 0.73 | HRH3 (0.45) | KMT2AMEN1GAATDP1 | |
| SCHEMBL6951008 | 0.73 | HRH3 (0.41) | HTR2AHTR7KCNH2DRD2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925766-A | COGNITION ACTIVATORS FOR DECREASING CHOLINERGIC FUNCTION OF ALZHEIMER*S DISEASE AND ARE ENZYME INHIBITORS OF MONOAMINE OXIDASE AND ARE ANTIDEPRESSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5756754-A | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds | HOECHST MARION ROUSSEL, INC. (US) | 1998-05-26 | — | — | US | disclosed |