Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376042 | 0.92 | SMN1; SMN2 (0.41) | CYP1A2ALDH1A1L3MBTL1ATMSMN1; SMN2 | |
| SCHEMBL8376002 | 0.87 | L3MBTL1 (0.39) | CYP1A2ALDH1A1L3MBTL1ATMSMN1; SMN2 | |
| SCHEMBL8377107 | 0.77 | CYP1A2 (0.39) | CYP1A2ALDH1A1HTR2AGAALMNA | |
| SCHEMBL8377218 | 0.75 | QPCT (0.40) | CYP1A2ALDH1A1L3MBTL1ATMSMN1; SMN2 | |
| SCHEMBL8377177 | 0.72 | ALDH1A1 (0.43) | CYP1A2ALDH1A1L3MBTL1LMNAKMT2A | |
| SCHEMBL8376040 | 0.71 | DRD3 (0.40) | CYP1A2ALDH1A1SMN1; SMN2GAALMNA | |
| SCHEMBL8377115 | 0.68 | MEN1 (0.37) | ALDH1A1L3MBTL1HTR1ADRD2HTR2A | |
| SCHEMBL6956977 | 0.67 | ACHE (0.39) | ALDH1A1SMN1; SMN2HTR1ADRD2HTR2A | |
| SCHEMBL3508760 | 0.66 | HTR2A (0.39) | ALDH1A1DRD2HTR2A | |
| SCHEMBL8183130 | 0.65 | CYP3A4 (0.47) | CYP1A2ALDH1A1SMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925766-A | COGNITION ACTIVATORS FOR DECREASING CHOLINERGIC FUNCTION OF ALZHEIMER*S DISEASE AND ARE ENZYME INHIBITORS OF MONOAMINE OXIDASE AND ARE ANTIDEPRESSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5756754-A | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds | HOECHST MARION ROUSSEL, INC. (US) | 1998-05-26 | — | — | US | disclosed |