Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381249 | 0.93 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1KDM4EEPHX2 | |
| SCHEMBL8377107 | 0.79 | CYP1A2 (0.39) | MAPK14LTB4RALDH1A1HPGDHSD17B10 | |
| SCHEMBL6651329 | 0.72 | LTB4R (0.44) | MEN1KMT2AMAPK14LTB4RALDH1A1 | |
| SCHEMBL8376040 | 0.72 | DRD3 (0.40) | ALDH1A1HPGDKDM4ENPC1EPHX2 | |
| SCHEMBL8375998 | 0.70 | GAA (0.37) | MEN1KMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL9212284 | 0.70 | ALDH1A1 (0.43) | KMT2AMAPK14LTB4RALDH1A1HPGD | |
| SCHEMBL6651331 | 0.69 | LTB4R (0.42) | MEN1KMT2AMAPK14LTB4RALDH1A1 | |
| SCHEMBL3504561 | 0.69 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL3505067 | 0.69 | ACHE (0.40) | ALDH1A1HPGDHSD17B10KDM4EHTR1A | |
| SCHEMBL8377217 | 0.68 | HTR2A (0.42) | MEN1KMT2ADRD2HTR2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925766-A | COGNITION ACTIVATORS FOR DECREASING CHOLINERGIC FUNCTION OF ALZHEIMER*S DISEASE AND ARE ENZYME INHIBITORS OF MONOAMINE OXIDASE AND ARE ANTIDEPRESSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5756754-A | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds | HOECHST MARION ROUSSEL, INC. (US) | 1998-05-26 | — | — | US | disclosed |