Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376594 | 0.84 | KDM1A (0.34) | KDM1A | |
| SCHEMBL8416556 | 0.79 | ITGB3 (0.34) | ITGB3ITGAVPBRM1IDO1KDM1A | |
| SCHEMBL7244240 | 0.79 | ITGB3 (0.34) | ITGB3ITGAVPBRM1IDO1KDM1A | |
| SCHEMBL8558738 | 0.79 | LMNA (0.39) | ITGB3ITGAVPBRM1IDO1 | |
| Hydrochloric Acid SCHEMBL8377740 | 0.77 | LMNA (0.42) | ITGB3ITGAVIDO1 | |
| SCHEMBL7242129 | 0.76 | PBRM1 (0.44) | PBRM1 | |
| Hydrochloric Acid SCHEMBL8380885 | 0.76 | PBRM1 (0.41) | PBRM1IDO1PIM1CDK2CSNK2A1 | |
| SCHEMBL2127072 | 0.73 | DPP4 (0.45) | — | |
| SCHEMBL642255 | 0.71 | CES2 (0.46) | KDM1A | |
| SCHEMBL642256 | 0.71 | CES2 (0.46) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883102-A | Pharmaceutically active compounds | ASTRA PHARMACEUTICALS LIMITED (GB) | 1999-03-16 | — | — | US | disclosed |
| EP-0858451-A1 | PHARMACEUTICALLY ACTIVE QUINAZOLINE COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997014686-A1 | PHARMACEUTICALLY ACTIVE QUINAZOLINE COMPOUNDS | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-04-24 | — | — | WO | disclosed |