Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | MASP2 | O00187 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 5/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8377740 | 0.98 | LMNA (0.42) | LMNABACE1ITGB3ITGAVMASP2 | |
| SCHEMBL20267431 | 0.85 | LMNA (0.40) | LMNABACE1ITGB3ITGAVF2 | |
| Hydrochloric Acid SCHEMBL7120718 | 0.80 | PRSS1 (0.39) | LMNAMASP2PLAUTHPOF2 | |
| Hydrochloric Acid SCHEMBL8376470 | 0.80 | PRSS1 (0.39) | LMNAMASP2PLAUTHPOF2 | |
| Hydrochloric Acid SCHEMBL8380885 | 0.80 | PBRM1 (0.41) | IDO1GAAPBRM1SLC2A1 | |
| SCHEMBL8377758 | 0.79 | ITGB3 (0.33) | ITGB3ITGAVIDO1PBRM1 | |
| SCHEMBL2127072 | 0.78 | DPP4 (0.45) | TP53TSHRGAASLC2A1 | |
| SCHEMBL4737570 | 0.75 | BACE1 (0.50) | LMNABACE1GAAPBRM1 | |
| Hydrochloric Acid SCHEMBL3717023 | 0.73 | BACE1 (0.49) | LMNABACE1GAAPBRM1 | |
| SCHEMBL20267890 | 0.73 | CES2 (0.37) | LMNAMASP2PLAUTHPOF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858451-A1 | PHARMACEUTICALLY ACTIVE QUINAZOLINE COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997014686-A1 | PHARMACEUTICALLY ACTIVE QUINAZOLINE COMPOUNDS | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-04-24 | — | — | WO | disclosed |