SCHEMBL8378992

SCHEMBL8378992

COCCOc1cc(OC)cc(Cl)c1OCCOC.O=C(CO)OC(c1ccccc1)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
KDM4E B2RXH2 2/20 0.39
KLK7 P49862 2/20 0.36
HTR1A P08908 2/20 0.35
ADRA1D P25100 2/20 0.35
ADRA1A P35348 2/20 0.35
ADRA1B P35368 2/20 0.35
PLAU P00749 1/20 0.35
MAPT P10636 2/20 0.35
MAPK1 P28482 2/20 0.35
HPGD P15428 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
TACR1 P25103 2/20 0.35
LMNA P02545 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CRHBP P24387 1/20 0.34
CRHR2 Q13324 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8380300 0.85 CYP2D6 (0.39) ALDH1A1HTR1AADRA1DADRA1AADRA1B
Glycolic Acid SCHEMBL8379193 0.82 ALDH1A1 (0.42) ALDH1A1L3MBTL1KDM4EPLAUMAPT
SCHEMBL8378914 0.82 HTR1A (0.39) ALDH1A1L3MBTL1KDM4EHTR1AADRA1D
SCHEMBL8636168 0.81 L3MBTL1 (0.47) ALDH1A1L3MBTL1KDM4EHTR1AADRA1D
SCHEMBL8378989 0.73 ALDH1A1 (0.36) ALDH1A1L3MBTL1KDM4EHTR1AADRA1D
SCHEMBL8664385 0.73 ALDH1A1 (0.38) ALDH1A1L3MBTL1KDM4EHTR1AADRA1D
SCHEMBL8382406 0.72 KLK7 (0.38) L3MBTL1KLK7
SCHEMBL8379003 0.71 ALDH1A1 (0.36) ALDH1A1L3MBTL1KDM4EHTR1AADRA1D
SCHEMBL8381832 0.71 ALDH1A1 (0.36) ALDH1A1L3MBTL1KDM4EHTR1AADRA1D
SCHEMBL8378913 0.71 ALDH1A1 (0.39) ALDH1A1L3MBTL1HTR1AADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5883248-A QUATERNARY AMMONIUM INTERMEDIATES ROUSSEL UCLAF (FR) 1999-03-16 US disclosed
US-5763617-A Cephalosporins ROUSSEL UCLAF (FR) 1998-06-09 US disclosed
US-5728828-A A 3-(3-CHLORO- OR IODOPROP-1-EN-1-YL),7-(2-AMINOTHIAZOL-4-YL) ((CARBOXY)(PHENYL)METHOXYIMINO)ACETAMIDO-3-CEPHEM; GRAMNEGATIVE AND -POSITIVE BACTERIA, ESP. ANTIBIOTIC-RESISTANCE STAPHYLOCOCCUS ROUSSEL UCLAF (FR) 1998-03-17 US disclosed
US-5712266-A Cephalosporins ROUSSEL UCLAF (FR) 1998-01-27 US disclosed