Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 5/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377184 | 0.84 | CYP11B1 (0.36) | ALDH1A1RAB9ALMNAKDM4EACHE | |
| SCHEMBL8376882 | 0.78 | ESR1 (0.39) | — | |
| SCHEMBL6953391 | 0.70 | KMT2A (0.37) | KMT2AALDH1A1MAP2K1BRAFRAF1 | |
| SCHEMBL8377051 | 0.68 | KDM4E (0.36) | KMT2AALDH1A1MEN1RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL8377570 | 0.64 | NCF1 (0.39) | KMT2AALDH1A1MEN1RAB9ALMNA | |
| SCHEMBL6651329 | 0.62 | LTB4R (0.44) | KMT2AALDH1A1MAP2K1BRAFFAAH | |
| SCHEMBL27835500 | 0.62 | RAB9A (0.72) | KMT2AALDH1A1MEN1RAB9ALMNA | |
| SCHEMBL6651331 | 0.60 | LTB4R (0.42) | KMT2AALDH1A1MAP2K1BRAFFAAH | |
| SCHEMBL9388748 | 0.60 | ALDH1A1 (0.40) | KMT2AALDH1A1LMNAKDM4EHTT | |
| SCHEMBL9211923 | 0.59 | NCEH1 (0.57) | KMT2AALDH1A1MEN1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925766-A | COGNITION ACTIVATORS FOR DECREASING CHOLINERGIC FUNCTION OF ALZHEIMER*S DISEASE AND ARE ENZYME INHIBITORS OF MONOAMINE OXIDASE AND ARE ANTIDEPRESSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5756754-A | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds | HOECHST MARION ROUSSEL, INC. (US) | 1998-05-26 | — | — | US | disclosed |