⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445888 | 0.78 | LMNA (0.55) | — | |
| SCHEMBL1410326 | 0.78 | — | — | |
| SCHEMBL7754183 | 0.76 | LMNA (0.59) | — | |
| SCHEMBL931358 | 0.76 | LMNA (0.59) | — | |
| SCHEMBL1409720 | 0.76 | ACE2 (0.45) | — | |
| SCHEMBL8812570 | 0.74 | LMNA (0.39) | — | |
| SCHEMBL8079439 | 0.74 | ACE2 (0.48) | — | |
| SCHEMBL14336195 | 0.74 | ACE2 (0.48) | — | |
| SCHEMBL10938434 | 0.74 | ACE2 (0.48) | — | |
| SCHEMBL448296 | 0.74 | ACE2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907666-A1 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. Searle & Co. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049736-A2 | PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS | G.D. SEARLE AND CO. (US) | 1997-12-31 | — | — | WO | disclosed |