Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 3/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | ESRRB | O95718 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8383452 | 0.87 | LMNA (0.46) | ALDH1A1GAAKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL8385080 | 0.85 | ELANE (0.54) | ELANEESR1ALDH1A1MAPTPPARA | |
| SCHEMBL8379886 | 0.84 | GAA (0.47) | ALDH1A1GAAMAPTPPARAKDM4E | |
| SCHEMBL8384112 | 0.83 | ESR1 (0.52) | ELANEESR1KDM4EPOLBMEN1 | |
| SCHEMBL8675359 | 0.82 | PKM (0.61) | ELANEESR1ESR2ALDH1A1GAA | |
| SCHEMBL8385011 | 0.81 | PKM (0.67) | ALDH1A1GAAPPARAHTT | |
| SCHEMBL8381329 | 0.81 | ALOX15 (0.59) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9517976 | 0.80 | ELANE (0.59) | ELANEESR1ALDH1A1GAAMAPT | |
| SCHEMBL8384111 | 0.80 | PPARA (0.55) | ESR1PPARA | |
| SCHEMBL8381057 | 0.79 | LMNA (0.52) | ESR1ESR2ALDH1A1KIF11SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874436-A | EFFECTIVE IN INHIBITING THE ACTION OF A BACTERIAL HISTIDINE PROTEIN KINASE; USEFUL AGAINST ANTIBIOTIC RESISTANT ORGANISMS | DEMERS JAMES P (US) | 1999-02-23 | — | — | US | disclosed |