Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.59 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.59 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.59 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.59 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.59 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.59 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.59 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.59 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.59 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.59 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.59 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.59 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.59 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.59 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.59 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.59 |
| ▸ | PSMA6 | P60900 | 1/20 | 0.59 |
| ▸ | PSMA8 | Q8TAA3 | 1/20 | 0.59 |
| ▸ | PSMB7 | Q99436 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9397244 | 0.82 | LMNA (0.70) | TP53PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL6478100 | 0.79 | CTSD (0.62) | TP53PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL24801410 | 0.78 | TP53 (1.00) | TP53HTTHPGDLMNAALDH1A1 | |
| SCHEMBL5856056 | 0.77 | ALDH1A1 (0.68) | TP53NPSR1HPGDSMPD1LMNA | |
| SCHEMBL24598450 | 0.77 | TP53 (0.63) | TP53PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL30098920 | 0.75 | MMP13 (0.59) | TP53MAPTHPGDALDH1A1MEN1 | |
| SCHEMBL30098939 | 0.75 | MMP13 (0.59) | TP53MAPTHPGDALDH1A1MEN1 | |
| SCHEMBL12855961 | 0.75 | ALDH1A1 (0.55) | TP53PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL24598578 | 0.74 | TP53 (0.60) | TP53PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL31743092 | 0.74 | LMNA (0.72) | TP53HTTMAPTNPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |