Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EPOR | P19235 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8383952 | 0.85 | HPGD (0.36) | HPGDALDH1A1KMT2A | |
| SCHEMBL8389354 | 0.77 | HPGD (0.34) | HPGDALDH1A1KMT2A | |
| SCHEMBL8519689 | 0.74 | HPGD (0.41) | LMNAHPGDALDH1A1KDM4ECYP3A4 | |
| SCHEMBL18594580 | 0.69 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAALDH1A1HTTKMT2A | |
| SCHEMBL29336444 | 0.69 | LMNA (0.54) | SMN1; SMN2LMNAALDH1A1KDM4ECYP3A4 | |
| SCHEMBL9470496 | 0.68 | ALDH1A1 (0.53) | SMN1; SMN2LMNAHPGDALDH1A1KDM4E | |
| SCHEMBL15784537 | 0.67 | LMNA (0.54) | SMN1; SMN2LMNAHPGDKDM4EHTT | |
| SCHEMBL29467688 | 0.67 | LMNA (0.49) | SMN1; SMN2LMNA | |
| SCHEMBL29467642 | 0.67 | LMNA (0.54) | SMN1; SMN2LMNAALDH1A1CYP3A4MAPK1 | |
| SCHEMBL20151955 | 0.67 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAHPGDKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793641-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1999-04-21 | — | — | EP | disclosed |
| US-5866717-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-02-02 | — | — | US | disclosed |
| EP-0793641-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016931-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-06-06 | — | — | WO | disclosed |