Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 2/20 | 0.34 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPRA | P18433 | 1/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | PTPRE | P23469 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16122323 | 0.82 | PTPRC (0.41) | ASPHKDM4EALDH1A1MAP2K1MAP2K2 | |
| SCHEMBL20680394 | 0.80 | KDM4E (0.42) | ASPHNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL22821086 | 0.80 | NOTUM (0.42) | ASPHNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL2387492 | 0.79 | ASPH (0.46) | ASPHNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL25111974 | 0.78 | EPRS1 (0.46) | ASPHNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL29334051 | 0.78 | ASPH (0.42) | ASPHNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL24566862 | 0.78 | KDM4E (0.43) | ASPHNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL30483541 | 0.78 | EPRS1 (0.46) | ASPHNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL695647 | 0.77 | CES2 (0.48) | ASPHNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL1044811 | 0.76 | MAP2K1 (0.45) | ASPHKDM4EMAP2K1MAP2K2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1064954-C | Orthosubstituted benzoylguanidine, preparation of same, pharmaceutical containing same and application of same | HOECHST AG (DE) | 2001-04-25 | — | — | CN | disclosed |
| US-5965744-A | ANTIARRHYTHMIC AGENT; TREATING OR PREVENTING INFARCTION, ANGINA PECTORIS; ANTIISCHEMIC AGENTS; SIDE EFFECT REDUCTION; ANTISHOCK AGENTS; ANTIALLERGENS | HOESCHST AKTIENGESELLSCHAFT (DE) | 1999-10-12 | — | — | US | disclosed |
| EP-0640588-B1 | Orthosubstituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent and a medicament containing them | HOECHST AG (DE) | 1999-09-08 | — | — | EP | disclosed |
| CN-1106381-A | Orthosubstituted benzoylguanidine, preparation of same, pharmaceutical containing same and application of same | HOECHST AG (DE) | 1995-08-09 | — | — | CN | disclosed |
| EP-0640588-A1 | Orthosubstituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent and a medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-03-01 | — | — | EP | disclosed |