Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | YAP1 | P46937 | 4/20 | 0.51 |
| ▸ | TEAD4 | Q15561 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339597 | 0.76 | KMT2A (0.37) | EPHX2YAP1TEAD4MAPK1MAPT | |
| SCHEMBL7038426 | 0.75 | RAB9A (0.57) | EPHX2YAP1TEAD4CYP3A4CYP2D6 | |
| SCHEMBL16797442 | 0.74 | ALDH1A1 (0.76) | EPHX2YAP1TEAD4CYP3A4CYP2D6 | |
| SCHEMBL8336540 | 0.71 | CNR2 (0.40) | ALDH1A1KMT2A | |
| SCHEMBL27691760 | 0.70 | EPHX1 (0.50) | EPHX2ALDH1A1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL10378518 | 0.70 | EPHX1 (0.50) | EPHX2ALDH1A1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL578174 | 0.70 | TSHR (0.59) | EPHX2CYP3A4CYP2C19TSHRNPC1 | |
| SCHEMBL5325204 | 0.70 | CCR8 (0.51) | YAP1TEAD4ALDH1A1TSHRMAPT | |
| SCHEMBL8335851 | 0.69 | CNR2 (0.38) | CYP3A4CYP2C19ALDH1A1HTTCYP1A2 | |
| SCHEMBL8338167 | 0.69 | HPGD (0.39) | MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |