Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 18/20 | 0.53 |
| ▸ | TPSD1 | Q9BZJ3 | 8/20 | 0.47 |
| ▸ | TPSG1 | Q9NRR2 | 8/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392137 | 0.89 | TPSAB1 (0.51) | TPSAB1TPSD1TPSG1 | |
| SCHEMBL8392373 | 0.88 | SIGMAR1 (0.46) | TPSAB1TPSD1TPSG1NOS1 | |
| SCHEMBL8396232 | 0.80 | TPSAB1 (0.56) | TPSAB1TPSD1TPSG1 | |
| Hydrochloric Acid SCHEMBL8481530 | 0.79 | TPSAB1 (0.55) | TPSAB1TPSD1TPSG1 | |
| SCHEMBL8392170 | 0.76 | NAMPT (0.43) | — | |
| Oxalic Acid SCHEMBL8392856 | 0.74 | HRH3 (0.42) | — | |
| SCHEMBL9218996 | 0.74 | NOS1 (0.54) | NOS3NOS1 | |
| SCHEMBL29221819 | 0.74 | HSP90AA1 (0.53) | — | |
| SCHEMBL6961451 | 0.73 | PPIB (0.57) | — | |
| SCHEMBL8395856 | 0.73 | HDAC2 (0.51) | TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |