Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.44 |
| ▸ | ESRRG | P62508 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392955 | 0.87 | ALDH1A1 (0.49) | ALDH1A1NPC1RAB9ASMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL8392055 | 0.86 | ALDH1A1 (0.48) | ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL8581493 | 0.82 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2POLBTPSAB1 | |
| SCHEMBL8583853 | 0.78 | HIF1A (0.57) | SMN1; SMN2TP53MCHR1CHRM1HTR2A | |
| SCHEMBL14469162 | 0.78 | NPC1 (0.84) | ALDH1A1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL11485844 | 0.78 | HTR3E (0.53) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL8394020 | 0.77 | HDAC3 (0.53) | ALDH1A1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8396232 | 0.77 | TPSAB1 (0.56) | ALDH1A1RAB9ALMNAPOLBTPSAB1 | |
| SCHEMBL8392009 | 0.77 | MCHR1 (0.50) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8393420 | 0.76 | MEN1 (0.61) | SMN1; SMN2MEN1KMT2ATPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |
| US-5998399-A | Guanidine derivatives useful in therapy as inhibitors of nitric oxide synthetase | ASTRA AKTIEBOLAG (SE) | 1999-12-07 | — | — | US | disclosed |
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | disclosed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | disclosed |