Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8399036 | 0.88 | MAOA (0.45) | ALOX5KDM4EMAOAMAOBKMT2A | |
| SCHEMBL8397950 | 0.81 | DRD2 (0.44) | KDM4ECYP1A2CYP2C9CYP3A4 | |
| SCHEMBL8395822 | 0.79 | TSHR (0.43) | MAOAMAOBKMT2A | |
| SCHEMBL2272581 | 0.79 | DRD2 (0.53) | KDM4ECYP1A2CYP2C9CYP3A4KMT2A | |
| SCHEMBL321366 | 0.78 | KDM1A (0.43) | ALOX5CYP1A2MAOAMAOB | |
| Ethane SCHEMBL11640556 | 0.78 | MAOB (0.46) | ALOX5KDM4EALDH1A1MAOBTACR1 | |
| SCHEMBL6730322 | 0.76 | DRD2 (0.47) | CYP1A2KMT2A | |
| SCHEMBL8396301 | 0.76 | DRD2 (0.44) | MAOAMAOBKMT2A | |
| Hydrochloric Acid SCHEMBL2523744 | 0.75 | OPRM1 (0.56) | CYP1A2MAOAMAOBTACR1 | |
| SCHEMBL16553890 | 0.75 | LMNA (0.56) | CYP1A2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912256-A | 0-(4-INDOLYLOXY)-3-(4-HYDROXY-4-NAPHTHYLPIPERIDIN-1-YL)PROPANE S | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0814084-A1 | Indole derivatives as 5-HT1A antagonists and as inhibitors of serotonine reuptake | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |