Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 9/20 | 0.45 |
| ▸ | MAOB | P27338 | 9/20 | 0.45 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8395673 | 0.88 | ALOX5 (0.54) | MAOAMAOBKDM4EKMT2AALOX5 | |
| SCHEMBL8400506 | 0.82 | KMT2A (0.61) | KDM4EKMT2AOPRM1SLC6A2SLC6A4 | |
| SCHEMBL8395822 | 0.82 | TSHR (0.43) | MAOAMAOBKMT2ASLC6A2SLC6A4 | |
| SCHEMBL8397950 | 0.79 | DRD2 (0.44) | KDM4EOPRM1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8396301 | 0.79 | DRD2 (0.44) | MAOAMAOBKMT2A | |
| SCHEMBL2272581 | 0.77 | DRD2 (0.53) | KDM4EKMT2ACYP2D6SLC6A2SLC6A4 | |
| SCHEMBL6730322 | 0.74 | DRD2 (0.47) | KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL6425545 | 0.73 | ALOX5 (0.67) | MAOAMAOBSLC16A3KDM4ENPC1 | |
| SCHEMBL8395305 | 0.72 | HTR1A (0.50) | KMT2ARAB9AOPRM1OPRD1OPRK1 | |
| SCHEMBL9374661 | 0.72 | MAOA (0.51) | MAOAMAOBOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912256-A | 0-(4-INDOLYLOXY)-3-(4-HYDROXY-4-NAPHTHYLPIPERIDIN-1-YL)PROPANE S | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0814084-A1 | Indole derivatives as 5-HT1A antagonists and as inhibitors of serotonine reuptake | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1997048698-A1 | COMPOUNDS HAVING EFFECTS ON SEROTONIN-RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |