Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 13/20 | 0.56 |
| ▸ | JUN | P05412 | 4/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.56 |
| ▸ | RELA | Q04206 | 4/20 | 0.56 |
| ▸ | ATF1 | P18846 | 10/20 | 0.50 |
| ▸ | XPO1 | O14980 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473934 | 0.88 | ATF1 (0.62) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL8394437 | 0.85 | KDM4E (0.56) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL8396865 | 0.81 | NFKB1 (0.58) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL8398281 | 0.80 | MAPT (0.49) | NFKB1JUNNFKB2RELAGAA | |
| SCHEMBL4564617 | 0.76 | ATF1 (0.45) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL1602748 | 0.76 | NFKB1 (0.46) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL30110408 | 0.76 | NFKB1 (0.46) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL21746957 | 0.74 | NFKB1 (0.55) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL8398500 | 0.73 | NFKB1 (0.53) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL21554055 | 0.73 | TSHR (0.45) | NFKB1JUNNFKB2RELAATF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935966-A | COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1998038171-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |