Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403575 | 0.82 | LMNA (0.45) | HTTLMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL11037236 | 0.80 | ABCB11 (0.50) | ABCB11PTGS2HTTCYP1A2LMNA | |
| SCHEMBL5219305 | 0.79 | ABCB11 (0.46) | ABCB11PTGS2HTTCYP1A2LMNA | |
| SCHEMBL8402112 | 0.79 | MAPT (0.47) | ABCB11PTGS2HTTCYP1A2LMNA | |
| SCHEMBL8401647 | 0.74 | ALDH1A1 (0.48) | ABCB11PTGS2HTTCYP1A2LMNA | |
| SCHEMBL8401815 | 0.72 | SRD5A2 (0.45) | ABCB11PTGS2TSHRSRD5A2HPGD | |
| SCHEMBL2760351 | 0.71 | ABCB11 (0.65) | ABCB11PTGS2HTTCYP1A2LMNA | |
| SCHEMBL5215390 | 0.71 | ABCB11 (0.39) | ABCB11PTGS2HTTCYP1A2LMNA | |
| SCHEMBL10920459 | 0.71 | KMT2A (0.44) | HTTLMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL30357971 | 0.70 | USP14 (0.50) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952368-A | AN INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE, ANTIINFLAMMATORY AND ANALGESIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1999-09-14 | — | — | US | disclosed |