SCHEMBL8400085

SCHEMBL8400085

CCc1ccc(N)c(C(=O)CCl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.50
MAPT P10636 3/20 0.50
HSD17B10 Q99714 2/20 0.50
KDM4E B2RXH2 1/20 0.50
GAA P10253 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
TSHR P16473 1/20 0.50
CDC25B P30305 1/20 0.47
CASP6 P55212 1/20 0.47
RCE1 Q9Y256 1/20 0.47
NOS2 P35228 2/20 0.43
MAPK1 P28482 1/20 0.40
HIF1A Q16665 1/20 0.40
RAB9A P51151 3/20 0.39
POLB P06746 1/20 0.39
HTT P42858 2/20 0.39
LMNA P02545 2/20 0.39
THRA P10827 1/20 0.38
THRB P10828 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8400087 0.87 ALDH1A1 (0.45) ALDH1A1MAPTHSD17B10KDM4EGAA
SCHEMBL9041416 0.86 ALDH1A1 (0.53) ALDH1A1MAPTHSD17B10KDM4EGAA
SCHEMBL17424893 0.81 GSK3B (0.42) ALDH1A1MAPTKDM4EGAAALOX15
SCHEMBL20670595 0.80 ALDH1A1 (0.54) ALDH1A1MAPTHSD17B10KDM4EGAA
SCHEMBL4097033 0.80 ALDH1A1 (0.54) ALDH1A1MAPTHSD17B10KDM4EGAA
SCHEMBL648210 0.80 ALDH1A1 (0.72) ALDH1A1MAPTHSD17B10KDM4EGAA
SCHEMBL8397350 0.79 RAB9A (0.53) ALDH1A1MAPTHSD17B10KDM4EHPGD
SCHEMBL11219888 0.78 THRB (0.57) ALDH1A1MAPTHSD17B10KDM4EGAA
SCHEMBL221403 0.77 ALDH1A1 (0.81) ALDH1A1MAPTHSD17B10KDM4EGAA
SCHEMBL2450666 0.77 ALDH1A1 (0.61) ALDH1A1ALOX15TSHRNOS2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0663899-B1 SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS UNIV MARYLAND (US) 1999-06-30 EP disclosed
EP-0919538-A1 Substituted kynurenines, a process for their preparation, and use as medicaments THE UNIVERSITY OF MARYLAND AT BALTIMORE (US) 1999-06-02 EP disclosed
US-5786508-A ENZYME INHIBITOR; COGNITION ACTIVATOR PHARMACIA & UPJOHN S.P.A. (IT) 1998-07-28 US disclosed
US-5708030-A COGNITION ACTIVATORS, PERINATAL BRAIN DISORDERS UNIVERSITY OF MARYLAND (US) 1998-01-13 US disclosed
US-5519055-A ENZYME INHIBITORS UNIVERSITY OF MARYLAND AT BALTIMORE (US) 1996-05-21 US disclosed
EP-0663899-A4 SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS. UNIV MARYLAND (US) 1996-01-17 EP disclosed
EP-0663899-A1 SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS THE UNIVERSITY OF MARYLAND AT BALTIMORE (US) 1995-07-26 EP disclosed
WO-1995004714-A1 SUBSTITUTED KYNURENINES, A PROCESS FOR THEIR PREPARATION, AND USE AS MEDICAMENTS UNIVERSITY OF MARYLAND AT BALTIMORE (US) 1995-02-16 WO disclosed