Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8401269 | 0.82 | GAA (0.44) | NR1H2NR1H3GAAMGLLKDM4E | |
| SCHEMBL8402405 | 0.74 | CASP3 (0.44) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27586782 | 0.67 | NR1H3 (0.70) | NR1H2NR1H3GAAMGLLLMNA | |
| SCHEMBL4431229 | 0.67 | GAA (0.49) | GAAKDM4EALDH1A1HPGDCDC25A | |
| SCHEMBL5800676 | 0.67 | GAA (0.49) | GAAKDM4EALDH1A1HPGDCDC25A | |
| SCHEMBL6690679 | 0.64 | NR1H3 (0.61) | NR1H2NR1H3ALDH1A1SMN1; SMN2 | |
| SCHEMBL8398953 | 0.63 | ITGB3 (0.42) | GAAKDM4EALDH1A1 | |
| SCHEMBL8401236 | 0.62 | MAPT (0.41) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11337352 | 0.62 | NR1H3 (0.67) | NR1H2NR1H3KDM4EALDH1A1HPGD | |
| SCHEMBL6879503 | 0.61 | CYP1A2 (0.47) | GAAKDM4EALDH1A1HPGDTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693636-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-02 | — | — | US | claimed |
| US-5939412-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-17 | — | — | US | disclosed |
| US-5693636-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |