Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6116181 | 1.00 | GAA (0.50) | GAAMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL6116186 | 1.00 | GAA (0.50) | GAAMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL20184057 | 0.89 | KMT2A (0.48) | GAAMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL20184054 | 0.89 | KMT2A (0.48) | GAAMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL2471431 | 0.87 | KDM4E (0.54) | GAAMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL2471433 | 0.87 | KDM4E (0.54) | GAAMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL9968899 | 0.84 | RAB9A (0.51) | GAAMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL2773603 | 0.84 | RECQL (0.56) | GAAMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL2773601 | 0.84 | RECQL (0.56) | GAAMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL406864 | 0.84 | KDM4E (0.47) | GAAMAPTKDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110337440-B | Compounds useful for inhibition of ROR-gamma-t | 伊莱利利公司 | 2021-08-03 | — | — | CN | disclosed |
| US-11008336-B2 | Compounds useful for inhibiting RORγt | ELI LILLY AND COMPANY (US) | 2021-05-18 | — | — | US | disclosed |
| US-11008336-B2 | Compounds useful for inhibiting RORγt | ELI LILLY AND COMPANY (US) | 2021-05-18 | — | — | US | disclosed |
| EP-3589638-B1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | LILLY CO ELI (US) | 2021-04-07 | — | — | EP | disclosed |
| EP-3589638-B1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | LILLY CO ELI (US) | 2021-04-07 | — | — | EP | disclosed |
| US-20200048279-A1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | ELI LILLY AND COMPANY | 2020-02-13 | — | — | US | disclosed |
| US-20200048279-A1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | ELI LILLY AND COMPANY | 2020-02-13 | — | — | US | disclosed |
| WO-2018160550-A1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | ELI LILLY AND COMPANY (US) | 2018-09-07 | — | — | WO | disclosed |
| US-20170327489-A1 | Bicycloheteroaryl-Heteroaryl-Benzoic Acid Compounds as Retinoic Acid Receptor Beta (RARBeta) Agonists | KING'S COLLEGE LONDON (GB) | 2017-11-16 | — | — | US | disclosed |
| US-9790213-B2 | Imidazoles for the treatment and prophylaxis of respiratory syncytial virus infection | HOFFMANN-LA ROCHE INC. (US) | 2017-10-17 | — | — | US | disclosed |
| WO-2016097004-A1 | BICYCLOHETEROARYL-HETEROARYL-BENZOIC ACID COMPOUNDS AS RETINOIC ACID RECEPTOR BETA (RARβ) AGONISTS | KING'S COLLEGE LONDON (GB) | 2016-06-23 | — | — | WO | disclosed |
| WO-2015110369-A1 | IMIDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2015-07-30 | — | — | WO | disclosed |
| WO-2015110369-A1 | IMIDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2015-07-30 | — | — | WO | disclosed |
| EP-2463279-B1 | 4-(1,2,4-dioxazol-3-yl)benzamides for the treatment of diabetes and obesity | DAIICHI SANKYO CO LTD (JP) | 2014-02-12 | — | — | EP | disclosed |
| US-8557802-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-10-15 | — | — | US | disclosed |
| US-8557802-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-10-15 | — | — | US | disclosed |
| EP-2463279-A1 | AMIDE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-06-13 | — | — | EP | disclosed |
| US-20120129832-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-05-24 | — | — | US | disclosed |
| US-20120129832-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-05-24 | — | — | US | disclosed |
| WO-2011016469-A1 | AMIDE DERIVATIVE | 第一三共株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129832-A1 | AMIDE DERIVATIVE | SLC5A1, SLC5A2, SLC2A1 | GAA 200/4885MAPT 3667/4885KDM4E 1909/4885 |
| US-20170327489-A1 | Bicycloheteroaryl-Heteroaryl-Benzoic Acid Compounds as Retinoic Acid Receptor Beta (RARBeta) Agonists | RARB, RARA, RXRB | GAA 2906/4885MAPT 2263/4885KDM4E 3575/4885 |
| US-11008336-B2 | Compounds useful for inhibiting RORγt | RORB, RORC, RORA | GAA 1756/4885MAPT 1598/4885KDM4E 1077/4885 |
| US-20200048279-A1 | COMPOUNDS USEFUL FOR INHIBITING ROR-GAMMA-T | RORC, RORB, RORA | GAA 1080/4885MAPT 2222/4885KDM4E 1476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.