SCHEMBL8405209

SCHEMBL8405209

CCOC(=O)c1cc(SF)c2c(c1Cl)C(=O)CCO2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.36
KDM4E B2RXH2 3/20 0.36
ALDH1A1 P00352 3/20 0.36
HPGD P15428 2/20 0.36
HSD17B10 Q99714 1/20 0.36
BAZ2B Q9UIF8 1/20 0.36
BAZ2A Q9UIF9 1/20 0.36
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
PREP P48147 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
MAPT P10636 2/20 0.33
LMNA P02545 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GAA P10253 1/20 0.33
CYP4F2 P78329 1/20 0.33
CYP4A11 Q02928 1/20 0.33
AKR1C3 P42330 1/20 0.33
AKR1C2 P52895 1/20 0.33
KMT2A Q03164 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8133198 0.92 NPSR1 (0.37) MAOBKDM4EALDH1A1HPGDHSD17B10
SCHEMBL8135015 0.81 NPSR1 (0.37) MAOBKDM4EALDH1A1HPGDHSD17B10
SCHEMBL6732023 0.75 BAZ2B (0.38) MAOBKDM4EALDH1A1HPGDHSD17B10
SCHEMBL8549368 0.74 ALDH1A1 (0.38) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
SCHEMBL8405173 0.73 KDM4E (0.32) KDM4EALDH1A1HPGDHSD17B10CA1
SCHEMBL19730583 0.70 NPSR1 (0.43) MAOBKDM4EALDH1A1HPGDHSD17B10
SCHEMBL8405207 0.70 KDM4E (0.38) MAOBKDM4EALDH1A1HPGDHSD17B10
SCHEMBL19973511 0.67 TSHR (0.49) MAOBKDM4EALDH1A1HPGDHSD17B10
SCHEMBL8137481 0.67 MAOB (0.39) MAOBKDM4EALDH1A1HSD17B10BAZ2B
SCHEMBL8133195 0.67 LMNA (0.40) MAOBKDM4EALDH1A1HSD17B10BAZ2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5863866-A HERBICIDES TO KILL WEEDS BUT NOT CROPS IDEMITSU KOSAN CO., LTD. (JP) 1999-01-26 US disclosed
EP-0819691-A1 PYRAZOLE DERIVATIVES IDEMITSU KOSAN COMPANY LIMITED (JP) 1998-01-21 EP disclosed