SCHEMBL8405668

SCHEMBL8405668

Cc1cc(C(F)(C(F)F)C(F)(F)F)cc(C)c1Oc1ccc(N)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
MAPT P10636 5/20 0.40
RAB9A P51151 4/20 0.40
NPC1 O15118 3/20 0.40
MAPK1 P28482 2/20 0.40
HPGD P15428 1/20 0.40
TEAD4 Q15561 1/20 0.40
TDP1 Q9NUW8 2/20 0.39
POLB P06746 1/20 0.39
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
AR P10275 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
MITF O75030 1/20 0.35
GAA P10253 1/20 0.35
GFER P55789 1/20 0.35
NLRP1 Q9C000 1/20 0.35
NOD2 Q9HC29 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21496204 0.90 RAB9A (0.36) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL8405569 0.84 ALDH1A1 (0.36) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL4854970 0.82 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL648768 0.81 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL8355667 0.81 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL29051422 0.80 HTT (0.44) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL21496116 0.79 RAB9A (0.42) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL28882083 0.79 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL4854975 0.78 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL27939455 0.78 HSP90AA1 (0.46) ALDH1A1MAPK1HPGDTDP1AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116574016-B Preparation method of 2,2- [4- (4-aminophenoxy) -3, 5-dimethylphenyl ] hexafluoropropane 山东阳谷华泰化工股份有限公司 2024-04-12 CN claimed
CN-116574016-A Preparation method of 2,2- [4- (4-aminophenoxy) -3, 5-dimethylphenyl ] hexafluoropropane 山东阳谷华泰化工股份有限公司 2023-08-11 CN claimed
CN-116574016-B Preparation method of 2,2- [4- (4-aminophenoxy) -3, 5-dimethylphenyl ] hexafluoropropane 山东阳谷华泰化工股份有限公司 2024-04-12 CN disclosed
CN-116574016-B Preparation method of 2,2- [4- (4-aminophenoxy) -3, 5-dimethylphenyl ] hexafluoropropane 山东阳谷华泰化工股份有限公司 2024-04-12 CN disclosed
CN-116574016-B Preparation method of 2,2- [4- (4-aminophenoxy) -3, 5-dimethylphenyl ] hexafluoropropane 山东阳谷华泰化工股份有限公司 2024-04-12 CN disclosed
CN-116574016-A Preparation method of 2,2- [4- (4-aminophenoxy) -3, 5-dimethylphenyl ] hexafluoropropane 山东阳谷华泰化工股份有限公司 2023-08-11 CN disclosed
CN-116574016-A Preparation method of 2,2- [4- (4-aminophenoxy) -3, 5-dimethylphenyl ] hexafluoropropane 山东阳谷华泰化工股份有限公司 2023-08-11 CN disclosed
CN-116574016-A Preparation method of 2,2- [4- (4-aminophenoxy) -3, 5-dimethylphenyl ] hexafluoropropane 山东阳谷华泰化工股份有限公司 2023-08-11 CN disclosed
US-5856065-A BLEND CONTAINING PHOTOINITIATOR AND ORGANOSILICON COMPOUND OLIN MICROELECTRONIC CHEMICALS, INC. (US) 1999-01-05 US disclosed