Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 14/20 | 0.41 |
| ▸ | USP14 | P54578 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409450 | 0.95 | KDM1A (0.40) | KDM1AHRH2HRH1 | |
| SCHEMBL8407654 | 0.89 | HRH2 (0.41) | KDM1AUSP14HRH2HRH1 | |
| SCHEMBL8407178 | 0.86 | KDM1A (0.38) | KDM1AUSP14CHRM3LRRK2 | |
| SCHEMBL8407652 | 0.83 | HRH2 (0.45) | KDM1AHRH2HRH1 | |
| SCHEMBL8407515 | 0.81 | KDM1A (0.38) | KDM1A | |
| SCHEMBL8409141 | 0.79 | USP14 (0.46) | KDM1AUSP14HRH2HRH1CHRM3 | |
| SCHEMBL8715693 | 0.79 | KDM1A (0.42) | KDM1ALRRK2 | |
| SCHEMBL5535336 | 0.76 | KDM4E (0.39) | KDM1AUSP14 | |
| SCHEMBL8718962 | 0.76 | CHRM4 (0.38) | KDM1A | |
| SCHEMBL5526338 | 0.75 | NOTUM (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |