Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 3/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407654 | 0.94 | HRH2 (0.41) | HRH2HRH1CETPFFAR4EGLN1 | |
| SCHEMBL8409450 | 0.88 | KDM1A (0.40) | HRH2HRH1EGLN1KDM1A | |
| SCHEMBL8409543 | 0.83 | KDM1A (0.41) | HRH2HRH1KDM1A | |
| SCHEMBL8718962 | 0.82 | CHRM4 (0.38) | KDM1ACHRM4 | |
| SCHEMBL9170067 | 0.80 | SIGMAR1 (0.59) | CHRM4CTSSCTSK | |
| SCHEMBL9174372 | 0.78 | CTSS (0.48) | KDM1ACHRM4CTSSCTSK | |
| SCHEMBL9175929 | 0.78 | CTSS (0.50) | CHRM4CTSSCTSK | |
| SCHEMBL7753345 | 0.77 | USP14 (0.52) | FFAR4CHRM4CTSSCTSK | |
| SCHEMBL8407515 | 0.76 | KDM1A (0.38) | KDM1A | |
| SCHEMBL5536327 | 0.75 | DGAT1 (0.37) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |