Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | ESRRB | O95718 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8412933 | 0.84 | KMT2A (0.42) | POLBLMNAKMT2AALDH1A1MAPT | |
| SCHEMBL16891423 | 0.80 | HSD17B3 (0.53) | POLBLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL8619424 | 0.80 | NR4A2 (0.52) | LMNAKMT2AALDH1A1HSD17B10RAB9A | |
| SCHEMBL8535748 | 0.74 | KMT2A (0.63) | POLBLMNAKMT2AALDH1A1MAPT | |
| SCHEMBL2305014 | 0.74 | HSD17B3 (0.60) | POLBLMNAKMT2AALDH1A1MAPT | |
| SCHEMBL8409414 | 0.74 | L3MBTL1 (0.40) | KMT2AALDH1A1MEN1TSHRL3MBTL1 | |
| SCHEMBL10638823 | 0.73 | KMT2A (0.48) | LMNAKMT2AALDH1A1MAPTHTT | |
| SCHEMBL640759 | 0.73 | LMNA (0.60) | POLBLMNAKMT2AALDH1A1MAPT | |
| SCHEMBL1108994 | 0.73 | MMP1 (0.70) | LMNAKMT2AALDH1A1MAPTHTT | |
| SCHEMBL9263357 | 0.73 | KMT2A (0.60) | POLBLMNAKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994540-A | HYDROXY- AND CHLORO-PYRIDYLPYRIDAZINONE DERIVATIVES | LONZA, LTD. (CH) | 1999-11-30 | — | — | US | disclosed |