Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.51 |
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409636 | 0.83 | MAOB (0.41) | MCL1PTGER1PPARAMAOB | |
| SCHEMBL8406725 | 0.81 | RXRA (0.70) | PTGER1RXRARXRBRXRGPTGER4 | |
| SCHEMBL8409730 | 0.80 | HTR1A (0.60) | MCL1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL9417935 | 0.78 | PDE5A (0.60) | MAOB | |
| SCHEMBL8318934 | 0.78 | HTR1A (0.60) | MCL1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8409884 | 0.78 | RXRA (0.49) | PTGER1RXRA | |
| SCHEMBL31482082 | 0.76 | KMT2A (0.54) | MCL1PTGER1RXRARXRBRXRG | |
| SCHEMBL12842098 | 0.76 | MAOB (0.57) | MCL1MAOB | |
| SCHEMBL8319789 | 0.76 | PTGER1 (0.67) | MCL1PTGER1PPARAPTGER4PTGER3 | |
| SCHEMBL8409837 | 0.75 | MRGPRX4 (0.52) | PTGER1RXRAMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778821-B1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LTD (GB) | 1999-10-20 | — | — | EP | disclosed |
| US-5965741-A | ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES | ZENECA LIMITED (GB) | 1999-10-12 | — | — | US | disclosed |
| EP-0778821-A1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LIMITED (GB) | 1997-06-18 | — | — | EP | disclosed |
| WO-1996006822-A1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LIMITED (GB) | 1996-03-07 | — | — | WO | disclosed |