Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.60 |
| ▸ | DRD2 | P14416 | 5/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 13/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.57 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.56 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318934 | 0.95 | HTR1A (0.60) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL8319789 | 0.88 | PTGER1 (0.67) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL6261880 | 0.83 | PPARA (0.55) | MCL1 | |
| SCHEMBL8409069 | 0.83 | ABCB1 (0.59) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL8319729 | 0.83 | ABCB1 (0.56) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL8321056 | 0.82 | FOLH1 (0.51) | PTGER1FOLH1 | |
| SCHEMBL8326478 | 0.82 | PTGER1 (0.57) | HTR1ADRD2ABCB1PTGER1PTGER4 | |
| SCHEMBL8406405 | 0.82 | THRA (0.43) | FOLH1 | |
| SCHEMBL8319605 | 0.80 | MTNR1A (0.58) | HTR1ADRD2ABCB1 | |
| SCHEMBL8409733 | 0.80 | MCL1 (0.53) | PTGER1PTGER4PTGER3PTGER2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778821-B1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LTD (GB) | 1999-10-20 | — | — | EP | disclosed |
| US-5965741-A | ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES | ZENECA LIMITED (GB) | 1999-10-12 | — | — | US | disclosed |
| EP-0778821-A1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LIMITED (GB) | 1997-06-18 | — | — | EP | disclosed |
| WO-1996006822-A1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LIMITED (GB) | 1996-03-07 | — | — | WO | disclosed |